- BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
Cell death & disease (2017-03-10)
Haijun Liu, Yusi Cheng, Jian Yang, Wei Wang, Shencun Fang, Wei Zhang, Bing Han, Zewei Zhou, Honghong Yao, Jie Chao, Hong Liao
PMID28277537
ABSTRACT
Following inhalation into the lungs, silica particles are engulfed by alveolar macrophages, which triggers endogenous or exogenous apoptosis signaling pathways. As an inducer of apoptosis, the role of BBC3/PUMA (BCL2-binding component 3) in macrophages during silicosis remains unknown. Here, we exposed U937 cell-derived macrophages (UDMs) to SiO
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Sigma-Aldrich
Anti-SMA antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP171, affinity isolated antibody