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The dorsal posterior insula subserves a fundamental role in human pain.

Nature neuroscience (2015-03-10)
Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar, Irene Tracey
ABSTRACT

Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.

MATERIALS
Product Number
Brand
Product Description

Supelco
Capsaicin, analytical standard
Capsaicin, European Pharmacopoeia (EP) Reference Standard
USP
Capsaicin, United States Pharmacopeia (USP) Reference Standard
Supelco
Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Capsaicin, ≥95%, from Capsicum sp.
Sigma-Aldrich
Capsaicin, natural
Sigma-Aldrich
Capsaicin, from Capsicum sp., ≥50% (HPLC)