biological source
human
Quality Level
recombinant
expressed in insect cells
assay
≥90% (SDS-PAGE)
form
lyophilized powder
potency
>0.004 units/mg
specific activity
≥40 units/μg
packaging
pkg of 5 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... GZMB(3002)
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General description
Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.
Biochem/physiol Actions
Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.
Unit Definition
One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37°C in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.
Physical form
Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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