SAB1300718

Anti-Phospho-APBB1-S347 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-APBB1, Anti-Amyloid β A4 precursor protein-binding family B member 1, Anti-FE65, Anti-Fe65 protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: 1:1000; western blot: 1:100-1:500
• NCBI accession no.: NP_001155.1
• UniProt accession no.: O00213
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer347)
• Gene Information: human ... APBB1(322)

Description

General description

APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer′s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product′s nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer′s disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.

Immunogen

APBB1 (NP_001155.1, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S347 of human APBB1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable