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About This Item

Empirical Formula (Hill Notation):
C14H13N
CAS Number:
7370-21-0
Molecular Weight:
195.26
MDL number:
MFCD02262120
UNSPSC Code:
12352200
PubChem Substance ID:
24278718
NACRES:
NA.77
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Quality Level

100

assay

>99%

form

solid

solubility

DMSO: 18 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(\C=C\c2ccccc2)n1

InChI

1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+

InChI key

SISOFUCTXZKSOQ-ZHACJKMWSA-N

Gene Information

human ... GRM1(2911), GRM5(2915)

Application

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem/physiol Actions

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 It also acts as a positive allosteric modulator of hmGluR4.2
Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
060K4603

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