Skip to Content
MilliporeSigma
Sign Into View Organizational & Contract Pricing

About This Item

Empirical Formula (Hill Notation):
C12H11N3O
CAS Number:
31993-01-8
Molecular Weight:
213.24
MDL number:
MFCD00506102
UNSPSC Code:
12352202
PubChem Substance ID:
24278717
NACRES:
NA.77
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥99% (HPLC)

form

crystalline

color

red

SMILES string

Cc1ccc(O)c(\N=N\c2ccccc2)n1

InChI

1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+

InChI key

LOCPVWIREQIGNQ-CCEZHUSRSA-N

Gene Information

human ... GRM1(2911), GRM5(2915)

Application

SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem/physiol Actions

SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
040K4605

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service