Name: NSCI
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₅N₃O₆S

CAS Number:

872254-32-5

Molecular Weight:

507.56

UNSPSC Code:

12352200

PubChem Substance ID:

24897488

NACRES:

NA.77

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Quality Level

100

assay

≥97% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL
H₂O: insoluble

storage temp.

−20°C

SMILES string

COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1

InChI

1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1

InChI key

XDHJBIYJRNFDKS-IBGZPJMESA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

Application

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

Biochem/physiol Actions

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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