Name: Loratadine
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₃N₂O₂Cl

CAS Number:

79794-75-5

Molecular Weight:

382.88

MDL number:

MFCD00672869

UNSPSC Code:

12352200

PubChem Substance ID:

24278525

NACRES:

NA.77

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Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: soluble 50 mg/mL
H₂O: insoluble

originator

Schering Plough

storage temp.

2-8°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)
rat ... Hrh1(24448)

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Loratadine is a non-sedating histamine H1-receptor antagonist. Shown to inhibit the two-pore domain potassium channel K2P18.1 (also called TRESK or KCNK18).

Non-sedating histamine H₁-receptor antagonist.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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