Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

K4389

Sigma-Aldrich

KR-32568

≥98% (HPLC), solid

Synonym(s):

[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C13H12FN3O2
CAS Number:
852146-73-7
Molecular Weight:
261.25
MDL number:
MFCD08705324
UNSPSC Code:
12352200
PubChem Substance ID:
24724522
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N

InChI

1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)

InChI key

DTLDHYBZLVASJQ-UHFFFAOYSA-N

Gene Information

human ... SLC9A1(6548)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML0912SML1890SML0243
KR-32568 ≥98% (HPLC), solid

K4389

KR-32568

SB 674042 ≥98% (HPLC)

SML0912

SB 674042

MK204 ≥98% (HPLC)

SML1890

MK204

ML169 ≥98% (HPLC)

SML0243

ML169

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ~10 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

DMSO: >5 mg/mL

color

white

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor.
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    056K46012
    056K46011
    056K4601

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Daniele Torella et al.
    Journal of the American Heart Association, 3(2), e000434-e000434 (2014-03-29)
    Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role in the diabetic cardiomyopathy is still unknown. We obtained left ventricular samples

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service