H5388

Hyaluronic acid sodium salt from rooster comb

avian glycosaminoglycan polysaccharide

• Synonym(s): Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
• CAS Number: 9067-32-7
• MDL number: MFCD01773053
• UNSPSC Code: 12352201
• PubChem Substance ID: 24895688
• NACRES: NA.25

Properties

• biological source: chicken (rooster comb)
• form: powder
• impurities: ≤2% protein (Lowry)
• color: white
• solubility: water: ~5 g/L
• cation traces: Na: 3-7%
• storage temp.: −20°C
• SMILES string: [Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
• InChI: 1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
• InChI key: YWIVKILSMZOHHF-QJZPQSOGSA-N

Description

Application

Hyaluronic acid sodium salt from rooster comb has been used:

• as a component of bi-layer gelatin scaffold[1]
• as a vehicle for release of gentamicin during left ear surgery in guinea pigs[2]
• in hyaluronic acid binding assay in human embryonic kidney cell line 293T[3]

Biochem/physiol Actions

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.

Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds.[4] Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle.[5] Hyaluronic acid also exhibits antioxidant and antiglycation properties.[6]

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves