H5388

Hyaluronic acid sodium salt from rooster comb

avian glycosaminoglycan polysaccharide

• Synonym(s): Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
• CAS Number: 9067-32-7
• MDL number: MFCD01773053
• UNSPSC Code: 12352201
• PubChem Substance ID: 24895688
• NACRES: NA.25

Properties

• biological source: chicken (rooster comb)
• form: powder
• impurities: ≤2% protein (Lowry)
• color: white
• solubility: water: ~5 g/L
• cation traces: Na: 3-7%
• storage temp.: −20°C
• SMILES string: [Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
• InChI: 1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
• InChI key: YWIVKILSMZOHHF-QJZPQSOGSA-N

Description

Application

Hyaluronic acid sodium salt from rooster comb has been used:

• as a component of bi-layer gelatin scaffold
• as a vehicle for release of gentamicin during left ear surgery in guinea pigs
• in hyaluronic acid binding assay in human embryonic kidney cell line 293T

Biochem/physiol Actions

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.

Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds. Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle. Hyaluronic acid also exhibits antioxidant and antiglycation properties.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves