MABS1922
Anti-Src-Like-Adaptor 2 (SLA2) Antibody, clone Z30P1F12*F4
clone Z30P1F12*F4, from mouse
Synonym(s):
Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43
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General description
Src-like-adapter 2 (UniProt: Q9H6Q3; also known as Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2) is encoded by the SLA2 (also known as SLAP2, C20orf156) gene (Gene ID 84174) in human. SLAP-2 is localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles. The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain. It is predominantly expressed in immune system, including T cells and monocytes and at low levels in B cells, placenta, prostate, colon, and skin. SLAP-2 serves as an adapter protein that negatively regulates T-cell receptor (TCR) signaling and is shown to block T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. In antigen receptor-stimulated cells, SLAP-2 associates with several tyrosine phosphorylated proteins, including the ubiquitin ligase Cbl. Deletion of the carboxyl terminus of SLAP-2 is shown to block its function and abolish its association with Cbl. Overexpression of SLAP-2 in T and B cell lines impairs antigen receptor-mediated signaling events, including the up-regulation of CD69, NFAT promoter activation, and calcium influx. Ref.: Holland, SJ et al. (2001). J. Exp. Med. 194(9):1263-1276. Pandey, A., et al. (2002). J. Biol. Chem. 277(21):19131-19138.
Specificity
Clone Z30P1F12*F4 detects -Src-Like-Adaptor 2 (SLA2) protein in human by targeting a sequence in the C-terminal region.
Immunogen
A synthetic peptide corresponding to 8 aa from the C-terminal region of human Src-like adapter 2 protein.
Application
Detect Src-like-adapter 2 using this mouse monoclonal Anti-Src-Like-Adaptor 2 (SLA2) antibody, clone Z30P1F12*F4, Cat. No. MABS1922, validated for use in Immunohistochemistry (Paraffin).
Research Category
Signaling
Signaling
Quality
Evaluated by Immunohistochemistry in human cervical cancer, pancreas, and tonsil tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Src-Like-Adaptor 2 (SLA2) in human cervical cancer, pancreas, and tonsil tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Src-Like-Adaptor 2 (SLA2) in human cervical cancer, pancreas, and tonsil tissue.
Target description
28.6 kDa calculated.
Physical form
Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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