Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

Substance P

RIA:
1:10,000 dilution from a previous lot was used in radioimmunioassay. 80% binding detects at least 5 pg/mL.

Optimal working dilutions must be determined by the end user.

Research Category
Neuroscience

Research Sub Category
Neuroinflammation & Pain

This Anti-Substance P Antibody, pain is validated for use in IH(P), RIA for the detection of Substance P.

Immunohistochemistry(paraffin):
Substance P (AB1566) representative staining pattern/morphology in Alzheimer’s brain. Tissue pretreated with Citrate pH6.0, antigen retrieval. Antibody diluted to 1:100.
IHC-Paraffin Staining With Citrate pH 6.0 Epitope Retrieval: Alzheimer’s Brain.

Rabbit polyclonal serum containing 0.1% sodium azide.

Unpurified

Stable for 1 year at -20ºC from date of receipt.

Control
Spinal Cord.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.