- Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides.
Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides.
Organic letters (2008-11-28)
Achim Porzelle, Michael D Woodrow, Nicholas C O Tomkinson
PMID19035839
ABSTRACT
The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 degrees C in toluene in the presence of Cs(2)CO(3) to give synthetically versatile N-arylhydroxylamine products in good to excellent yield.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
5-(Di-tert-butylphosphino)-1ā², 3ā², 5ā²-triphenyl-1ā²H-[1,4ā²]bipyrazole, 97%