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  • Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.

Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.

Indian journal of experimental biology (2014-10-28)
Nattapon Supkamonseni, Aree Thinkratok, Duangdeun Meksuriyen, Rungrudee Srisawat
ABSTRACT

In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of alpha-glucosidase activity by C. asiatica extract, rutin, and acarbose was not different. The in vivo study substantiated the in vitro results. C. asiatica extract (1000 and 2000 mg/4 mL/kg), rutin (1000 mg/4 mL/kg), and orlistat (45 mg/4 mL/kg) significantly decreased plasma glucose, triglyceride and total cholesterol levels in lipid emulsion-induced hyperlipidemic rats at 3 h. However, plasma aspartate aminotransferase and alanine aminotransferase levels did not show significant change. The present work further supports that the C. asiatica extract and its bioactive rutin may help managing hypolipidemic and hypoglycemic effects.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Nitrophenyl β-D-glucuronide, ≥99.0% (TLC)
Pricing and availability is not currently available.
Supelco
Rutin trihydrate, analytical standard
Pricing and availability is not currently available.
Supelco
Sodium carbonate, reference material for titrimetry, certified by BAM, >99.5%
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Sodium carbonate, anhydrous, powder, 99.999% trace metals basis
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Rutin trihydrate, primary reference standard
Pricing and availability is not currently available.
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Sodium carbonate, BioXtra, ≥99.0%
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Sodium carbonate, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E500, anhydrous, 99.5-100.5% (calc. to the dried substance)
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Sodium carbonate, anhydrous, free-flowing, Redi-Dri, ACS reagent (primary standard), 99.95-100.05% dry basis
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, anhydrous, powder or granules, free-flowing, Redi-Dri, ACS reagent, ≥99.5%
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Sigma-Aldrich
Sodium carbonate, anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99.5%
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Sigma-Aldrich
Sodium carbonate, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.5%
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, ACS reagent, anhydrous, ≥99.5%, powder or granules
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, ACS reagent (primary standard), anhydrous, 99.95-100.05% dry basis
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, ReagentPlus®, ≥99.5%
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, BioUltra, anhydrous, ≥99.5% (calc. on dry substance, T)
Pricing and availability is not currently available.
Sigma-Aldrich
4-Nitrophenyl β-D-glucuronide, ≥98% (TLC)
Pricing and availability is not currently available.
Sigma-Aldrich
Sodium carbonate, powder, ≥99.5%, ACS reagent
Pricing and availability is not currently available.
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Acarbose, ≥95% (HPLC)
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Supelco
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Acarbose, Pharmaceutical Secondary Standard; Certified Reference Material
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Supelco
Sodium carbonate concentrate, Na2CO3 72 mM in water, IC eluent concentrate (20x) for Metrosep A Supp 7
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Acarbose, European Pharmacopoeia (EP) Reference Standard
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Rutoside trihydrate, European Pharmacopoeia (EP) Reference Standard
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