- Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]triazolo[4,3-a]pyridines.
Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]triazolo[4,3-a]pyridines.
Organic letters (2010-01-27)
Andreas Reichelt, James R Falsey, Robert M Rzasa, Oliver R Thiel, Michal M Achmatowicz, Robert D Larsen, Dawei Zhang
PMID20099864
ABSTRACT
An efficient and convenient method for the synthesis of [1,2,4]triazolo[4,3-a]pyridines was exemplified by the synthesis of 20 analogues bearing a variety of substituents at the 3-position. The methodology involves a palladium-catalyzed addition of hydrazides to 2-chloropyridine, which occurs chemoselectively at the terminal nitrogen atom of the hydrazide, followed by dehydration in acetic acid under microwave irradiation.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity