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About This Item
Linear Formula:
HOC6H4CH(CH2NHCH3)OH·HCl
CAS Number:
Molecular Weight:
203.67
Beilstein:
4158948
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
(R)-(−)-Phenylephrine hydrochloride, powder
form
powder
Quality Level
mp
143-145 °C (lit.)
originator
Johnson & Johnson
SMILES string
OC1=CC([C@H](CNC)O)=CC=C1.Cl
InChI
1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
InChI key
OCYSGIYOVXAGKQ-FVGYRXGTSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
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General description
(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.
Application
(R)-(-)-Phenylephrine hydrochloride has been used:
- in the preparation and culturing of cardiocytes and fibroblasts
- to stimulate myocardial strips to measure slice contraction
- in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
- to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
- to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality
Biochem/physiol Actions
α1-adrenoceptor agonist.
Features and Benefits
This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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