Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
Molecular Weight:
278.31
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
form
solid
Quality Level
color
white
solubility
H2O: ≥43 mg/mL, colorless to almost colorless
originator
Sanofi Aventis
SMILES string
CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
InChI key
MQGNNJQTNFHNHK-UHFFFAOYSA-N
Gene Information
human ... ADORA2B(136), LITAF(9516), PDE4B(5142), TNF(7124)
rat ... Tnf(24835)
Looking for similar products? Visit Product Comparison Guide
Related Categories
Application
Pentoxifylline has been used:
- used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
- to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
- to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
Biochem/physiol Actions
Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Lact.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service