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About This Item
Empirical Formula (Hill Notation):
C15H12O4
CAS Number:
Molecular Weight:
256.25
Beilstein:
1914296
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
form
powder
Quality Level
color
yellow to orange
solubility
H2O: <0.1 mg/mL
methanol: 10 mg/mL
DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
Gene Information
rat ... Alox5(25290)
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General description
Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food.
Application
Isoliquiritigenin has been used:
- as a bone morphogenetic protein (BMP) agonist in zebrafish embryos
- as a guanylyl cyclase activator in zebrafish embryos
- to test its antitumor and antiviral effects against Epstein-Barr virus-associated gastric carcinoma
Biochem/physiol Actions
Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Caution
Photosensitive, hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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