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About This Item
Empirical Formula (Hill Notation):
C17H27NO2 · HCl
CAS Number:
Molecular Weight:
313.86
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
ICI 118,551 hydrochloride, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >10 mg/mL
SMILES string
Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
InChI
1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
InChI key
KBXMBGWSOLBOQM-LINSIKMZSA-N
Gene Information
human ... ADRB2(154)
Related Categories
Application
ICI 118,551 hydrochloride has been used:
- to block β-adrenergic signaling in various experiments
- to counteract degradation by endogenous T-lymphocyte monoamine oxidases
- to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts
Biochem/physiol Actions
ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.
ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Caution
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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