W332208

Thiamine hydrochloride

≥98%, FCC, FG

• Synonym(s): Aneurine hydrochloride, Vitamin B₁ hydrochloride
• Empirical Formula (Hill Notation): C₁₂H₁₇ClN₄OS · HCl
• CAS Number: 67-03-8
• Molecular Weight: 337.27
• FEMA Number: 3322
• Beilstein: 3851771
• EC Number: 200-641-8
• Council of Europe no.: 4226
• MDL number: MFCD00012780
• UNSPSC Code: 12164502
• PubChem Substance ID: 24901639
• Flavis number: 16.027
• NACRES: NA.21
• grade: FG; Halal; Kosher
• biological source: synthetic
• food allergen: no known allergens

Properties

• biological source: synthetic
• Quality Level: 400
• grade: FG; Halal; Kosher
• Agency: meets purity specifications of JECFA
• reg. compliance: EU Regulation 1334/2008 & 872/2012; FCC
• Assay: ≥98%
• form: powder or crystals
• color: white to yellow-white
• mp: 250 °C (dec.) (lit.)
• solubility: H₂O: 1 g/10 mL, clear, colorless

Description

General description

Thiamine hydrochloride is a water-soluble vitamin generally used as a nutrient supplement. When it undergoes heat-degradation, it may form volatile flavor compounds such as hydrogen sulfide, 2-methylthiopehene, 2-methylfuran, and 4,5-dihydro-2-methylthiophene.

Application

• Construction of hyaluronic acid-functionalized magnolol nanoparticles for ulcerative colitis treatment.: This innovative study explores the synthesis of nanoparticle systems using hyaluronic acid-functionalized magnolol, highlighting thiamine hydrochloride′s role in enhancing therapeutic efficacy and stability in gastrointestinal treatments. This research underlines the biochemical application of thiamine hydrochloride in developing advanced drug delivery systems (Li Y et al., 2024).


• Constructing Highly Stable Zinc Metal Anodes via Induced Zn(002) Growth.: Investigates the electrochemical stability of zinc anodes, with thiamine hydrochloride playing a critical role in modulating the electrochemical properties and enhancing the anode′s performance, showcasing its potential in next-generation battery technologies (Hu S et al., 2024).


• Subclinical thiamine deficiency results in failed reproduction in Arctic foxes.: This study identifies the pivotal role of thiamine hydrochloride in preventing reproductive failures linked to nutritional deficiencies in wildlife, extending its application beyond human health to include environmental and conservation aspects (Jackson C et al., 2024).


• Density Functional Theory and Density Functional Tight Binding Studies of Thiamine Hydrochloride Hydrates.: Highlights computational studies on the molecular structure and stability of thiamine hydrochloride, providing crucial insights into its physicochemical properties and interactions at the molecular level, critical for pharmaceutical formulations (Napiórkowska E et al., 2023).


• Effects of Nutrients on the Growth of and Free Exopolysaccharide Biosynthesis by Streptococcus thermophilus 937 in a Chemically Defined Medium.: Examines the influence of thiamine hydrochloride among other nutrients on the microbial synthesis processes, underlining its essential role in microbial nutrition and metabolic engineering (Wa Y et al., 2023).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves