933589
NanoFabTx™ NanoFlash PEG Lipid Mix
for CIJ synthesis of PEGylated liposomes
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50 ML
SGD 355.00
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50 ML
SGD 355.00
About This Item
UNSPSC Code:
12352211
NACRES:
NA.21
Recommended Products
Quality Level
storage temp.
−20°C
1 of 4
This Item | 79888 | 45368 | 1269414 |
|---|---|---|---|
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level - |
| solubility pyridine: soluble 1%, clear, very faintly brownish-yellow | solubility - | solubility - | solubility - |
| mp >300 °C (lit.) | mp >300 °C (lit.) | mp >300 °C (lit.) | mp >300 °C (lit.) |
| form powder | form - | form - | form - |
| functional group amine | functional group - | functional group - | functional group - |
Application
NanoFabTx™ NanoFlash PEG Lipid Mix a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing PEGylated liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types PEGylated liposomes are capable of encapsulating both hydrophilic and lipophilic compounds and are an effective mechanism to increase the efficiency of drug delivery by prolonging the lifetime of the drug-encapsulated liposome.
This lipid mix has been curated and designed for flash nanoprecipitiaton (FNP) synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.
This lipid mix has been curated and designed for flash nanoprecipitiaton (FNP) synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.
Features and Benefits
- A ready-to-use nanoformulation lipid blend for the synthesis of PEGylated liposomes
- Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- Optimized lipid blend for stealth PEGylated liposomes for small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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D Papahadjopoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
Jing Han et al.
Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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