P2443

Pluronic^® F-127

powder, BioReagent, suitable for cell culture

• Synonim(y): Niejonowy kopolimerowy środek powierzchniowo czynny
• Wzór liniowy: (C₃H₆O·C₂H₄O)x
• CAS Number: 9003-11-6
• Numer MDL: MFCD00082049
• Kod UNSPSC: 12161902
• Identyfikator substancji w PubChem: 24897874
• NACRES: NA.75

Właściwości

• opis: Non-ionic; contains 100ppm BHT
• linia produktu: BioReagent
• Formularz: powder
• masa cząsteczkowa: ~12600 g/mol
• metody: cell culture | mammalian: suitable
• CMC: 950-1000 ppm (~25°C)
• temp. przejścia: cloud point >100 °C
• HLB: 18 - 23
• ciąg SMILES: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• Klucz InChI: RVGRUAULSDPKGF-UHFFFAOYSA-N

Opis

Opis ogólny

Pluronicpluronic^® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

Zastosowanie

Pluronic^® F-127 has been used:

• as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
• as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
• in the preparation of calcium indicator stock solution for measuring neural activities.
• as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
• This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

Działania biochem./fizjol.

Pluronic^® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic^® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

Informacje prawne

Pluronic is a registered trademark of BASF

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)