H4791

BMP2, human

BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

• Synonim(y): Białko morfogenetyczne kości 2 ludzkie
• Numer MDL: MFCD03097877
• Kod UNSPSC: 12352202
• NACRES: NA.77

Właściwości

• Product Name: Bone Morphogenetic Protein 2 human, BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture
• pochodzenie biologiczne: human
• Poziom jakości: 100
• rekombinowane: expressed in HEK 293 cells
• Formularz: lyophilized powder
• siła działania: ≤60 ng/mL EC₅₀
• jakość: endotoxin tested
• masa cząsteczkowa: dimer 30-38 kDa (glycosylated)
• opakowanie: pkg of 10 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: ≤1 EU/μg Endotoxin level
• numer dostępu UniProt: P12643
• temp. przechowywania: −20°C
• informacje o genach: human ... BMP2(650)

Opis

Opis ogólny

Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.

Działania biochem./fizjol.

It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.

Uwaga dotycząca przygotowania

This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.

Komentarz do analizy

The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).

Informacje prawne

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable