- Maternal Dead-end 1 promotes translation of
Maternal Dead-end 1 promotes translation of
Development (Cambridge, England) (2017-09-06)
Tristan Aguero, Zhigang Jin, Sandip Chorghade, Auinash Kalsotra, Mary Lou King, Jing Yang
PMID28870987
ABSTRACT
In the developing embryo, primordial germ cells (PGCs) represent the exclusive progenitors of the gametes, and their loss results in adult infertility. During early development, PGCs are exposed to numerous signals that specify somatic cell fates. To prevent somatic differentiation, PGCs must transiently silence their genome, an early developmental process that requires Nanos activity. However, it is unclear how Nanos translation is regulated in developing embryos. We report here that translation of
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Monoclonal ANTI-FLAG® M2 antibody produced in mouse, 1 mg/mL, clone M2, affinity isolated antibody, buffered aqueous solution (50% glycerol, 10 mM sodium phosphate, and 150 mM NaCl, pH 7.4)