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Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Molecules (Basel, Switzerland) (2015-10-02)

Thomas M Kohl, Christian H Hornung, John Tsanaktsidis

초록

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

MATERIALS

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제품 설명

Sigma-Aldrich

Methylamine solution, 2.0 M in methanol

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Methylamine solution, 2.0 M in THF

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Methylamine solution, 40 wt. % in H₂O

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Ammonia solution, 2.0 M in isopropanol

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Ammonia solution, 7 N in methanol

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Ammonia solution, 0.4 M in dioxane

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Ammonia solution, 2.0 M in methanol

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Ammonia solution, 2.0 M in ethanol

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Ammonia solution, 4 M in methanol

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Ammonia-¹⁴N, 99.99 atom % ¹⁴N

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Methylamine solution, 33 wt. % in absolute ethanol ((denatured with 1% toluene))

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Ammonia solution, 0.4 M in THF

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Isopropyl alcohol, ≥99.7%, FCC, FG

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Methanol, suitable for NMR (reference standard)

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Methanol, anhydrous, 99.8%

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Methanol, HPLC Plus, ≥99.9%, poly-coated bottles

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Methanol, ACS spectrophotometric grade, ≥99.9%

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Methanol, puriss., meets analytical specification of Ph Eur, ≥99.7% (GC)

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Methanol, ACS reagent, ≥99.8%

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Methanol, Absolute - Acetone free

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Methanol, ACS reagent, ≥99.8%

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Methanol, BioReagent, ≥99.93%

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Methanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

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Methanol, ACS reagent, ≥99.8%

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Methanol, Laboratory Reagent, ≥99.6%

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2-Propanol, puriss. p.a., ACS reagent, ≥99.8% (GC)

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Dimethyl sulfoxide, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

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Isopropyl alcohol, meets USP testing specifications

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2-Propanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

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2-Propanol, puriss., meets analytical specification of Ph. Eur., BP, USP, ≥99.5% (GC)