- 7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Journal of medicinal chemistry (2004-03-19)
Diane H Boschelli, Yanong D Wang, Steve Johnson, Biqi Wu, Fei Ye, Ana Carolina Barrios Sosa, Jennifer M Golas, Frank Boschelli
PMID15027848
초록
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
MATERIALS