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일반 설명
MYC oncogene is a global transcription factor. The gene is located on human chromosome 8q24.21. MYC oncogene is a cancer promoting gene.
생화학적/생리학적 작용
C-Myc is a transcription factor, often deregulated in cancer, that promotes cell proliferation, growth, differentiation, and apoptosis.
C-myc oncogene has high proliferative capacity. Overexpression of this gene is associated with Burkitt lymphoma. C-myc oncogene is implicated in various malignant tumors, such as, leukemia, lymphoma and human solid tumor.
The universal deregulation of c-Myc gene expression in tumor cells suggests that this oncogene represents an attractive target for cancer therapeutic purposes. The c-Myc promoter integrates diverse mitogenic signaling cascades, which are constitutively activated in tumor cells, and translates them into expression of the c-Myc transcription factor, which promotes cell proliferation, growth, differentiation, and apoptosis by regulating the expression of numerous target genes. The structural and biochemical features of the MYC family (MYC, N-MYC, and L-MYC) mark them as direct regulators of gene expression. As basic helix-loop-helix leucine zipper proteins (bHLH-ZIP), the MYCs acquire the capacity to bind the DNA sequence CACGTG (E-box) when dimerized with MAX (another bHLH-ZIP, 4,5). A head-to-tail pair of MYC-MAX dimers may, in turn, form a heterotetramer capable of bridging distant E-boxes. Among the broadly distributed positive enforcers of MYC action that are often recruited to target genes are chromatin remodeling (SWI/SNF relatives) and modifying complexes (TRAPP/GCN5 and relatives); these complexes mobilize nucleosomes and acetylate histones and/or other targets to activate gene expression. MYC binds TBP along an auxiliary pathway to control gene expression. MAD and MNT generally oppose MYC action by enlisting histone deacetylase complexes. Besides acting at the level of chromatin, MYC may also operate at later stages of the transcription cycle, after pre-initiation complex formation. In addition to using generic chromatin complexes to up- or down-regulate transcription, the MYC network also conscripts individual factors to modify expression locally on an ad hoc basis. For example, YY1, AP2, MIZ1, SP1, BRCA1, and other proteins interact directly with MYC, and so may directly modify the output of the MYC network.
물리적 형태
Clear and colorless frozen liquid solution
제조 메모
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
C V Dang et al.
Experimental cell research, 253(1), 63-77 (1999-12-02)
The c-myc gene and the expression of the c-Myc protein are frequently altered in human cancers. The c-myc gene encodes the transcription factor c-Myc, which heterodimerizes with a partner protein, termed Max, to regulate gene expression. Max also heterodimerizes with
Deconstructing myc.
R N Eisenman
Genes & development, 15(16), 2023-2030 (2001-08-21)
Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
Guo T, et al.
Genes Chromosomes Cancer, 50(1), 25-33 (2011)
Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection
Ji F, et al.
BMC Cancer, 18(1), 460-460 (2018)
Novel synthetic 4-chlorobenzoyl berbamine inhibits c-Myc expression and induces apoptosis of diffuse large B cell lymphoma cells
Zhang L, et al.
Annals of Hematology, 97(12), 2353-2362 (2018)
문서
We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.
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