Name: Prostaglandin E<SUB>1</SUB>
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₂₀H₃₄O₅

CAS Number:

745-65-3

Molecular Weight:

354.48

Beilstein:

5294062

EC Number:

212-017-2

MDL number:

MFCD00077860

UNSPSC 코드:

12352211

eCl@ss:

42020658

PubChem Substance ID:

57654538

NACRES:

NA.77

기술 서비스

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도움 문의

Product Name

Prostaglandin E₁, ≥98% (HPLC), synthetic

생물학적 소스

synthetic

Quality Level

200

분석

≥98% (HPLC)

양식

(powder to crystals)

solubility

ethanol: 5 mg/mL

저장 온도

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

유전자 정보

human ... PTGER1(5731), PTGER2(5732), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

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애플리케이션

Prostaglandin E1 has been used:

as a platelet inhibitor to analyse its effect on autophagy
in platelet adhesion assay
to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

생화학적/생리학적 작용

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).