Name: PD 98,059
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₆H₁₃NO₃

CAS Number:

167869-21-8

Molecular Weight:

267.28

MDL number:

MFCD00671789

UNSPSC 코드:

12352200

PubChem Substance ID:

24278666

NACRES:

NA.77

기술 서비스

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도움 문의

양식

solid

Quality Level

100

색상

yellow

solubility

DMSO: 10 mg/mL, clear

저장 온도

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

유전자 정보

human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)

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애플리케이션

PD 98,059 has been used:

in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
in culture medium for cell migration assay

생화학적/생리학적 작용

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.