Name: Mecamylamine hydrochloride
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₁H₂₁N · HCl

CAS Number:

826-39-1

Molecular Weight:

203.75

EC Number:

212-555-8

MDL number:

MFCD00151462

UNSPSC 코드:

12352116

PubChem Substance ID:

24277851

NACRES:

NA.77

기술 서비스

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Product Name

Mecamylamine hydrochloride,

양식

powder

Quality Level

200

solubility

ethanol: 122 mg/mL
H₂O: 47 mg/mL
isopropanol: 476 mg/mL
glycerol: 95 mg/mL

주관자

AstraZeneca

SMILES string

Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C

InChI

1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1

InChI key

PKVZBNCYEICAQP-CIISUUNXSA-N

유전자 정보

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

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애플리케이션

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.

생화학적/생리학적 작용

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.