Name: Hexamethonium bromide
Brand: SIGMA

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About This Item

Linear Formula:

(CH₃)₃N(Br)(CH₂)₆N(Br)(CH₃)₃

CAS Number:

55-97-0

Molecular Weight:

362.19

Beilstein:

3715749

EC Number:

200-249-7

MDL number:

MFCD00011787

UNSPSC 코드:

12352200

PubChem Substance ID:

24278459

NACRES:

NA.77

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Quality Level

200

mp

282-285 °C (dec.)

SMILES string

[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C

InChI

1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

InChI key

FAPSXSAPXXJTOU-UHFFFAOYSA-L

유전자 정보

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

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애플리케이션

Hexamethonium bromide has been used:

as an autonomic ganglia-blocking agent to study its effects on whisker movement in rats
as a nicotinic receptor antagonist to study its effects on antigen-induced arthritis (AIA) progression in mice
as a non-selective ganglionic nicotinic acetylcholine receptor (nAChR) antagonist to study its effects on cytisine-induced autonomic cardiovascular responses in mice

생화학적/생리학적 작용

Hexamethonium bromide is a nicotinic acetylcholine receptor (nAChR) antagonist. It preferentially blocks nicotinic receptors at autonomic ganglia. It can cross the blood-brain barrier only at high doses.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.