Name: Dexamethasone
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₂₂H₂₉FO₅

CAS Number:

50-02-2

Molecular Weight:

392.46

Beilstein:

2066651

EC Number:

200-003-9

MDL number:

MFCD00064136

UNSPSC 코드:

51422306

PubChem Substance ID:

24893536

NACRES:

NA.77

기술 서비스

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도움 문의

Product Name

Dexamethasone, ≥98% (HPLC), powder

Quality Level

200

분석

≥98% (HPLC)

양식

powder

색상

off-white

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

주관자

Merck & Co., Inc., Kenilworth, NJ, U.S.

저장 온도

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

유전자 정보

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

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일반 설명

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways, some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

애플리케이션

Dexamethasone has been used:

in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
as a component of adipocyte differentiation medium
for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

생화학적/생리학적 작용

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.

Glucocorticoid anti-inflammatory agent

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

제조 메모

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

재구성

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

픽토그램

GHS08

신호어

Danger

유해 및 위험 성명서

H360FD

예방조치 성명서

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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시험 성적서(COA)

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