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Merck
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주요 문서

T-032

Supelco

(−)-Δ8-THC solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

실험식(Hill 표기법):
C21H30O2
CAS Number:
Molecular Weight:
314.46
EC Number:
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

certified reference material

Quality Level

양식

liquid

특징

Snap-N-Spike®/Snap-N-Shoot®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

drug control

Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

농도

1.0 mg/mL in methanol

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

cannabis testing
cannabis testing

형식

single component solution

저장 온도

−20°C

SMILES string

O1C(C2C(CC(=CC2)C)c3c1cc(cc3O)CCCCC)(C)C

InChI

1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9,12-13,16-17,22H,5-8,10-11H2,1-4H3

InChI key

HCAWPGARWVBULJ-UHFFFAOYSA-N

일반 설명

A certified solution standard suitable for LC/MS or GC/MS applications in cannabinoid testing, clinical toxicology, forensic analysis, or urine drug testing. Δ8-THC is an impurity in synthetic THC manufacturing processes. Δ8-THC is the double bond isomer of the primary psychoactive ingredient of cannabis called Δ9-tetrahydrocannabinol. This cannabinoid has antiemetic, anxiolytic, appetite-stimulating, and analgesic properties.

애플리케이션

The Certified Spiking Solution® is suitable for (−)-Δ8-THC testing by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. The Certified Reference Material (CRM) in solution can also be used as follows:
  • Multi-analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Separation and estimation of 13 cannabinoids from different cannabis products using isocratic high-performance liquid chromatography (HPLC) in combination with a diode array detector (DAD)
  • Gas chromatographic-mass spectrometric (GC-MS) analysis of ten main cannabinoids from hemp inflorescences following their silylation and esterification for derivatization
  • Quantification of cannabidiol and Δ9-tetrahydrocannabinol in addition to the identification of minor cannabinoids from human plasma samples using ultra-performance liquid chromatography (UHPLC) combined with triple quadrupole mass spectrometry following a liquid-liquid extraction
  • QuEChERS based extraction of 15 cannabinoids from 20 food product samples followed by their quantification by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

특징 및 장점

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

관련 제품

제품 번호
설명
가격

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

51.8 °F - closed cup

Flash Point (°C)

11.0 °C - closed cup


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Ketan Hippalgaonkar et al.
AAPS PharmSciTech, 12(2), 723-731 (2011-06-04)
The purpose of this study was to investigate the effect of cyclodextrins (CDs) on aqueous solubility, stability, and in vitro corneal permeability of delta-8-tetrahydrocannabinol (Δ(8)-THC). Phase solubility of Δ(8)-THC was studied in the presence of 2-hydroxypropyl-β-cyclodextrin (HPβCD), randomly methylated-β-cyclodextrin (RMβCD)
S H Burstein et al.
Life sciences, 56(23-24), 1991-1998 (1995-01-01)
Binding and photoactivation of a cannabinoid-derived ligand to intact mouse peritoneal cells has resulted in the labelling of a G-protein gamma-subunit. The assignment of structure is based on the product's physical characteristics and its ability to react with a polyclonal
S Muchtar et al.
Ophthalmic research, 24(3), 142-149 (1992-01-01)
delta 8-Tetrahydrocannabinol (delta 8-THC), a known antiglaucoma lipophilic drug, was incorporated in a submicron emulsion for ocular administration. The mean droplet size of the emulsion was 130 +/- 41 nm, and no droplet was larger than 400 nm. No change
B R Martin et al.
Pharmacology, biochemistry, and behavior, 46(2), 295-301 (1993-10-01)
One aspect of cannabinoid structure-activity relationships (SARs) that has not been thoroughly investigated is the aromatic (A) ring. Although halogenation of the side chain enhances potency, our recent observation that iodination of the A ring also enhanced activity was surprising.
Donna A Whyte et al.
Pharmacology, 85(6), 328-335 (2010-06-03)
The primary cannabinoids, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) are known to disturb the mitochondrial function and possess antitumor activities. These observations prompted us to investigate their effects on the mitochondrial O(2) consumption in human oral cancer cells (Tu183). This epithelial

문서

As the popularity of cannabis-infused products increases, there is a growing need to characterize the type and content of the cannabinoids found in the product. This application demonstrates the ability of the Ascentis Express C18 column to baseline resolve 14 structurally-similar cannabinoids, in under seven minutes, with excellent peak shape.

Tetrahydrocannabinolic acid A solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material.

The cannabinoids found in the Cannabis plant commonly referred to as marijuana, have grown in popularity for treating a variety of ailments from arthritis, glaucoma, and chronic pain to malnutrition, multiple sclerosis, and cancer.

프로토콜

Potency testing in marijuana-infused edibles is an important problem that analytical labs are facing due to the complexity of the involved matrices. Concentration of active ingredients in these edibles can range from a few parts per million to 3.5 parts per thousand. This application demonstrates the extraction and HPLC-UV analysis of the active compounds.

As the popularity of cannabis-infused products increases, there is a growing need to characterize the type and content of the cannabinoids found in the product. This application demonstrates the ability of the Ascentis Express C18 column to baseline resolve 14 structurally-similar cannabinoids, in under seven minutes, with excellent peak shape.

Rapid potency testing of marijuana-infused edibles using LC/MS on a biphenyl stationary phase detected eleven cannabinoids.

Tetrahydrocannabinolic acid A solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Cannabichromenic Acid (CBCA) solution, 1.0 mg/mL in acetonitrile, certified reference material, ampule of 1 mL

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