NCF4
neutrophil cytosolic factor 4, 40kDa
동의어:
NCF, P40PHOX, SH3PXD4
종:
Human NCF4 (4689), Mouse Ncf4 (17972), Rat Ncf4 (500904), sheep NCF4 (101122939), naked mole-rat Ncf4 (101699188), Domestic Rabbit NCF4 (100009359), domestic guinea pig Ncf4 (100729267), Zebrafish ncf4 (403014), chicken NCF4 (418052), domestic cat NCF4 (101095507) ...더
UniProtKB ID:
Clone ID:
- Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17972) neutrophil cytosolic factor 4
- Rat(500904) neutrophil cytosolic factor 4
- sheep(101122939) neutrophil cytosolic factor 4, 40kDa
- naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa
- Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
- domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
- Zebrafish(403014) neutrophil cytosolic factor 4
- chicken(418052) neutrophil cytosolic factor 4, 40kDa
- domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
- cow(507859) neutrophil cytosolic factor 4, 40kDa
- Horse(100069566) neutrophil cytosolic factor 4, 40kDa
- dog(481277) neutrophil cytosolic factor 4, 40kDa
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
제품 번호
설명
종별 반응성
응용분야
Monoclonal Anti-NCF4 antibody produced in mouse, clone 3C10, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
종별 반응성
human
응용분야
immunofluorescence
Anti-NCF4/P40PHOX antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
canine, human
응용분야
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-NCF4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
western blot
Anti-Phospho-NCF4-T154 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Proteins
제품 번호
설명
종