Name: Tropisetron monohydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₀N₂O₂ · HCl

CAS Number:

105826-92-4

Molecular Weight:

320.81

MDL number:

MFCD00210221

UNSPSC Code:

12352200

PubChem Substance ID:

24278133

NACRES:

NA.77

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Assay

≥98% (HPLC)

form

solid

solubility

H₂O: >10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

InChI

1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H

InChI key

XIEGSJAEZIGKSA-UHFFFAOYSA-N

Gene Information

human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)

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Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Biochem/physiol Actions

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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