Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C12H10N2
CAS Number:
Molecular Weight:
182.22
Beilstein:
143898
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
drug control
stupéfiant (France)
mp
235-238 °C (lit.)
solubility
methanol: soluble 50mg/ml
SMILES string
Cc1nccc2c3ccccc3[nH]c12
InChI
1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
InChI key
PSFDQSOCUJVVGF-UHFFFAOYSA-N
Gene Information
human ... CYP2D6(1565)
rat ... Gabra2(29706)
Looking for similar products? Visit Product Comparison Guide
General description
- Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
- It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
- Blood harmane concentration is elevated in essential tremor, late-life neurological disease.
Application
- Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
- It was used to study interactions of norharman and harman with DNA.
- It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Biochem/physiol Actions
I1 imidazoline binding site agonist.
Preparation Note
Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service