CD59
CD59 molecule, complement regulatory protein
Synonyms:
16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
Species:
Human CD59 (966), Rat Cd59 (25407), Zebrafish cd59 (335928), chicken CD59 (423148), cow CD59 (505574), domestic cat CD59 (101092210), dog CD59 (475945), sheep CD59 (101102670), Domestic Rabbit CD59 (100009459), naked mole-rat Cd59 (101726814)
UniProtKB ID:
Gene ID:
- Human(966) Summary: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
- Rat(25407) CD59 molecule, complement regulatory protein
- Zebrafish(335928) CD59 molecule, complement regulatory protein
- chicken(423148) CD59 molecule, complement regulatory protein
- cow(505574) CD59 molecule, complement regulatory protein
- domestic cat(101092210) CD59 molecule, complement regulatory protein
- dog(475945) CD59 molecule, complement regulatory protein
- sheep(101102670) CD59 molecule, complement regulatory protein
- Domestic Rabbit(100009459) CD59 molecule, complement regulatory protein
- naked mole-rat(101726814) CD59 molecule, complement regulatory protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD59 antibody produced in mouse, clone MEM-43/5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
flow cytometry
Anti-CD59 Antibody, clone 2/24, clone 2/24, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
immunofluorescence
Anti-CD59 Antibody, clone 2/24, FITC conjugated, clone 2/24, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
immunofluorescence
Anti-CD59 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-CD59-FITC antibody produced in mouse, clone MEM-43, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
esiRNA
Product Number
Description
Species