H7379

Hemoglobin human

lyophilized powder

• Synonym(s): Hb
• CAS Number: 9008-02-0
• MDL number: MFCD00131282
• UNSPSC Code: 12352202
• eCl@ss: 42030116
• NACRES: NA.61

Properties

• biological source: human
• form: lyophilized powder
• technique(s): enzyme immunoassay: suitable
• impurities: HIV and hepatitis B antigen, tested negative
• solubility: H₂O: soluble 20 mg/mL
• UniProt accession no.: P02008; P02042; P02100; P09105; P68871; P69891; P69892; P69905
• storage temp.: 2-8°C
• Gene Information: human ... HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048), HBQ1(3049), HBZ(3050)

Description

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Application

Hemoglobin was used in the development of a rapid enzyme immunoassay for the detection of retinol-binding protein. It was also used in the inhibition of human platelet reactivity by endothelium-derived relaxing factor.

Biochem/physiol Actions

Oxygen transporter, NO scavenger

The Fe²⁺/Fe³⁺ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.

Caution

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable