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About This Item
Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
Molecular Weight:
161.07
Beilstein:
3906680
EC Number:
MDL number:
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.75
biological source
microbial
synthetic
product line
BioReagent
Assay
≥97% (TLC)
form
powder
technique(s)
cell culture | mammalian: suitable
mp
280 °C (dec.) (lit.)
solubility
H2O: 100 mg/mL
SMILES string
Cl[H].Cl[H].NCCCCN
InChI
1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
InChI key
XXWCODXIQWIHQN-UHFFFAOYSA-N
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General description
Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.
Application
Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.
Biochem/physiol Actions
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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