SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
Synonyms:
BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
Species:
Human SCNN1A (6337), Mouse Scnn1a (20276), Rat Scnn1a (25122), cow SCNN1A (282348), sheep SCNN1A (443488), naked mole-rat Scnn1a (101700410), domestic guinea pig Scnn1a (100135613), chicken SCNN1A (396050), domestic cat SCNN1A (101091122), dog SCNN1A (403650)
UniProtKB ID:
Gene ID:
- Human(6337) Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
- Mouse(20276) sodium channel, nonvoltage-gated 1 alpha
- Rat(25122) sodium channel, nonvoltage-gated 1 alpha
- cow(282348) sodium channel, non-voltage-gated 1 alpha subunit
- sheep(443488) sodium channel, non-voltage-gated 1 alpha subunit
- naked mole-rat(101700410) sodium channel, non-voltage-gated 1 alpha subunit
- domestic guinea pig(100135613) sodium channel, nonvoltage-gated 1 alpha
- chicken(396050) sodium channel, non-voltage-gated 1 alpha subunit
- domestic cat(101091122) sodium channel, non-voltage-gated 1 alpha subunit
- dog(403650) sodium channel, non-voltage-gated 1 alpha subunit
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