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Merck

PDE4A

phosphodiesterase 4A, cAMP-specific

Synonyms:
DPDE2, PDE4, PDE46
Species:
UniProtKB ID:
Gene ID:
  • Human(5141) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(18577) phosphodiesterase 4A, cAMP specific
  • Rat(25638) phosphodiesterase 4A, cAMP-specific
  • Zebrafish(572061) phosphodiesterase 4A, cAMP-specific
  • chicken(769860) phosphodiesterase 4A, cAMP-specific
  • dog(100683695) phosphodiesterase 4A, cAMP-specific
  • domestic cat(751107) phosphodiesterase 4A, cAMP-specific
  • cow(512222) phosphodiesterase 4A, cAMP-specific
  • sheep(101117505) phosphodiesterase 4A, cAMP-specific
  • domestic guinea pig(100135594) phosphodiesterase 4A, cAMP-specific
  • naked mole-rat(101717168) phosphodiesterase 4A, cAMP-specific
  • Domestic Rabbit(100009247) phosphodiesterase 4A, cAMP-specific

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Small Molecule - Antagonist

Product Number
Description
Species
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid,
Species
human, rat
Theophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human
Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline, phyproof® Reference Substance,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Ibudilast, ≥99% (HPLC), solid,
Species
human
Zaprinast, solid,
Species
human
Roflumilast, ≥98% (HPLC),
Species
human
Amlexanox, ≥98% (HPLC),
Species
human
7-(2,3-Dihydroxypropyl)theophylline, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PDE4A (3),
Species
human
MISSION® esiRNA, targeting human PDE4A,
Species
human
MISSION® esiRNA, targeting human PDE4A (2),
Species
human
MISSION® esiRNA, targeting mouse Pde4a,
Species
mouse